Biologic Orthopedics Journal

COMPARATIVE ANALYSIS OF A FIRST AND SECOND-GENERATION COMMERCIALLY AVAILABLE PLATELET-RICH PLASMA CONCENTRATION SYSTEM

2025-05-11T16:28:21+00:00

Background: The use of orthobiologics, particularly platelet-rich plasma (PRP), has become increasingly prevalent for the treatment of musculoskeletal pathologies. However, there is limited research comparing the PRP yields from different commercially available systems. In 2024, the second-generation EmCyte PurePRP® TWO GenesisCS 120 mL Concentrating System was released, and the GS120-PurePRP® II 120mL Concentrating System was retired.

Methods: This study evaluates the platelet concentrate products from these two PRP systems. A retrospective review of registry data from 20 consecutive patients treated with intra-articular PRP injections for knee osteoarthritis (OA) was conducted. Platelet recovery rate, deliverable platelet dose, and white (WBC) and red blood cell (RBC) counts were analyzed.

Results: There were no statistically significant differences in platelet recovery (P = 0.4094) or deliverable platelet dose (P = 0.4104) between the two systems.

Conclusion: Platelet recovery rate and dose, WBC and RBC counts were similar between the newly released and legacy systems.

THE ORTHOBIOLOGICS USE IN KICKING ATHLETES: A REVIEW PAPER

2025-03-15T17:02:28+00:00

Abstract

Background: In recent years, orthobiologics have gained a substantial interest for the treatment of various sports related musculoskeletal injuries. However, their use and effectiveness remain controversial.

Objectives: In this review, the current literature on the use of orthobiolgoics for sports related injury among kicking athletes was reviewed. The primary goal of the paper is to provide an evidence-based resource for clinicians on the orthobiologics treatment in kicking athletes.

Data Sources: Eligible studies were identified through searches of PubMed, ScienceDirect, and Embase up to May 22, 2024. The search terms included “orthobiologics”, “platelet-rich plasma”, “platelet-poor plasma”, “PRP”, “PPP”, bone-marrow aspirate concentrate”, “mesenchymal stem cell”, “BMAC”, “MSC”, “ultrasound guided hydrodissection”, “ultrasound guided hydrodilatation”, “ultrasound guided percutaneous tenotomy”, “barbotage”, “ultrasound guided ablation”, “kicking sport athletes”, “soccer player”, “placekicker”, “futsal”, “football”, and “soccer”.

Main results: The initial literature search yielded 2264 articles after duplicates were excluded. After screening titles and abstracts, 138 articles were assessed for eligibility. Following the full-text evaluation, a total of 20 articles were included in the final analysis. Of the 20 studies, 2 were randomized control trials, 1 was a retrospective cohort study, 4 were case series, and 13 were case reports. The average Coleman Methodology Score modified for conservative therapy for all included studies is 30.30 (range 18-74) and overall the quality is in the poor range.

Conclusions: While platelet-rich plasma and prolotherapy appear to be a safe adjunctive treatment, comparison and outcome interpretation are limited due to the nature of heterogeneity of the PRP protocols and pathologies reported among reviewed studies. Future studies are warranted to evaluate orthobiologics treatment, focusing on protocols including the timing, dosing/concentration, and number of injections, to allow clinicians to understand utility of orthobiologics treatment when treating kicking athletes.

CLINICAL APPLICATIONS OF AUTOLOGOUS MICROFRAGMENTED ADIPOSE TISSUE IN CHRONIC TENDINOUS INJURIES: A NARRATIVE REVIEW

2025-03-25T15:40:43+00:00

Tendinopathy is a multifactorial condition influenced by both intrinsic and extrinsic factors, necessitating a tailored, phased-based management approach. While first-line management traditionally involves conservative measures, limited success in chronic cases has galvanized interest in orthobiologic interventions. Autologous lipoaspirate-derived microfragmented adipose tissue (MFAT), a minimally manipulated ortho-biologic, has demonstrated potential in managing chronic tendinopathy. This narrative review explores the clinical application of MFAT in the nonoperative management of chronic tendinous pathologies, focused on preprocedural management, procedural standardization, post-injection protocols, and outcome assessment.